CST, 14098T, MORF4L1/MRG15 (D2Y4J) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying MORF4L1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, MORF4L1/MRG15 (D2Y4J) Rabbit Monoclonal Antibody (CST #14098) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity MORF4L1/MRG15 (D2Y4J) Rabbit Monoclonal Antibody recognizes endogenous levels of total MORF4L1/MRG15 protein. This antibody may recognize a 90 kDa protein of unknown origin in some cells. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala237 of human MORF4L1/MRG15 protein. Background Mortality factor 4-like protein 1 (MORF4L1/MRG15) is a chromo domain-containing protein that is part of several histone modifying complexes, including the Tip60 histone acetyltransferase (HAT) complex, histone deacetylase (HDAC) complexes, and the JARID1A and JARID1B histone demethylase complexes (1-6). MORF4L1/MRG15 recognizes di- or trimethylated Lys36 of histone H3 through its chromo domain. This interaction recruits and anchors MORF4L1/MRG15-associated chromatin modifying complexes to target genes for transcriptional regulation (7,8). MORF4L1/MRG15 plays a role in DNA repair as part of the Tip60 HAT complex (9,10). MORF4L1/MRG15 regulates alternative splicing during co-transcriptional splicing of mRNA as a part of the JARID1A complex (11). MORF4L1/MRG15 recruitment of the JARID1B complex to embryonic stem cell renewal-associated genes is important for repression of cryptic transcription and maintenance of proper transcriptional elongation (6). Alternate Names Eaf3; Esa1p-associated factor 3 homolog; FWP006; HsT17725; MEAF3; MGC10631; MO4L1; MORF-related gene 15 protein; MORF-related gene on chromosome 15; MORF4L1; MORFRG15; mortality factor 4 like 1; Mortality factor 4-like protein 1; MRG15; Protein MSL3-1; S863-6; Transcription factor-like protein MRG15 Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 40 Source/Isotype: Rabbit IgG