{"product_id":"cst-14243t","title":"CST,  14243T, FANCB (D9W6S) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying FancB. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, FANCB (D9W6S) Rabbit Monoclonal Antibody (CST #14243) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nFANCB (D9W6S) Rabbit Monoclonal Antibody recognizes endogenous levels of total FANCB protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro280 of human FANCB protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nFanconi anemia (FA) is an autosomal recessive genetic disorder resulting in symptoms that include chromosomal breakage, bone marrow failure, hypersensitivity to DNA cross-linking agents (such as mitomycin C), and a predisposition to cancer (1). FANCB is an X-linked member of the FA nuclear complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCM). In response to DNA damage, the FA nuclear complex induces mono-ubiquitination of FANCD2 and FANCI (2). FANCJ\/BRIP1, FANCD1\/BRCA2, and FANCN\/PALB2 are then recruited to sites of DNA damage along with other DNA repair proteins. FA signaling is important in maintenance of chromosome stability and control of mitosis (3). Studies of FANCB knockout embryonic stem cells suggest a role for FANCB in the formation of Rad51 and FANCD2 foci at chromosomal sites of DNA damage (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFA complementation group B; FA2; FAAP90; FAAP95; FAB; FACB; FANCB; Fanconi anemia complementation group B; Fanconi anemia group B protein; Fanconi anemia-associated polypeptide of 95 kDa; Fanconi anemia, complementation group B; Protein FACB; type 2 Fanconi pancytopenia\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 90\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797607010473,"sku":"14243T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14243t","provider":"Iright","version":"1.0","type":"link"}