{"product_id":"cst-14288t","title":"CST,  14288T, PATL1\/PAT1b (D8P1B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PATL1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, PATL1\/PAT1b (D8P1B) Rabbit Monoclonal Antibody (CST #14288) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPATL1\/PAT1b (D8P1B) Rabbit Monoclonal Antibody recognizes endogenous levels of total PATL1\/PAT1b protein. This antibody does not cross-react with PATL2.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Tyr432 of human PATL1\/PAT1b protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPATL1\/PAT1b is the human homolog of the evolutionarily conserved Pat1\/Mrt1 protein, which was first identified in (1,2). This protein is a critical component of the RNA decay machinery in the cytoplasmic processing bodies (P-bodies), localized foci of mRNA silencing and degradation (3). PATL1\/PAT1b interacts with many key components of the RNA decay machinery. These include the 5' decapping proteins DDX6\/RCK, DCP1, DCP2, EDC4, and the LSm1-7 ring (3,4) as well as the 3' deadenylation complex of CAF1-CCR4-NOT1 (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nFLJ36874; hPat1b; MGC125671; MGC125672; PAT1 homolog 1, processing body mRNA decay factor; PAT1-like protein 1; Pat1b; PATL1; protein associated with topoisomerase II homolog 1; protein associated with topoisomerase II homolog 1 (yeast); Protein PAT1 homolog 1; Protein PAT1 homolog b\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 95\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797607403689,"sku":"14288T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14288t","provider":"Iright","version":"1.0","type":"link"}