{"product_id":"cst-14364t","title":"CST,  14364T, IGF-II Receptor\/CI-M6PR (D3V8C) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying IGF2R. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, IGF-II Receptor\/CI-M6PR (D3V8C) Rabbit Monoclonal Antibody (CST #14364) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nImmunofluorescence (Immunocytochemistry): 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. For a carrier free (BSA and azide free) version of this product see product # 33388 .\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIGF-II Receptor\/CI-M6PR (D3V8C) Rabbit mAb recognizes endogenous levels of total IGF-II Receptor\/CI-M6PR protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala1675 of human IGF-II Receptor\/CI-M6PR protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nInsulin-like growth factor II (IGF-II) receptor, also widely known as cation-independent mannose 6-phosphate receptor (CI-M6PR), is a multifunctional type I transmembrane glycoprotein that participates in the internalization of mannose-6-phosphate modified hydrolases and IGF-II from the plasma membrane (1,2). In the absence of ligands, IGF-II receptor is constitutively endocytosed from the cell surface to accumulate in the Golgi apparatus (3). In the presence of ligands, the receptor transports the mannose-6-phosphate modified hydrolases to acidified endosomes and lysosomes (4). The ligand-free receptor is then transported back to the Golgi compartment or the cell surface (4). In several research studies, IGF-II receptor has been recognized as a tumor suppressor in a number of cancers (5-7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n300 kDa mannose 6-phosphate receptor; cation-independent mannose-6 phosphate receptor; Cation-independent mannose-6-phosphate receptor; CD222; CI Man-6-P receptor; CI-M6PR; CI-MPR; CIMPR; IGF-II receptor; IGF2R; insulin like growth factor 2 receptor; Insulin-like growth factor 2 receptor; Insulin-like growth factor II receptor; M6P-R; M6P\/IGF2 receptor; M6P\/IGF2R; M6PR; MPR 300; MPR1; MPR300; MPRI\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 275\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797608550569,"sku":"14364T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14364t","provider":"Iright","version":"1.0","type":"link"}