CST, 14365S, Rab38 (D2V9Z) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying RAB38. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Rab38 (D2V9Z) Rabbit Monoclonal Antibody (CST #14365) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity Rab38 (D2V9Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total Rab38 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu114 of human Rab38 protein. Background Rab38 is a member of the Rab small G protein family and is mainly expressed in lung alveolar type II cells and melanocytes (1,2). In mice, the G146T Rab38 gene mutation results in loss of Rab38 function and causes abnormal pigmentation due to the loss of melanosomes (3). The Rab38 gene locus has been mapped to oculocutaneous albinism in Ruby rats, a model of human Hermansky-Pudlak Syndrome (4). Analysis of lung structure in the G146T mutation in mice and the Rab38 null mutation in rats also revealed an altered lung surfactant system with enlarged lamellar bodies in type II cells, indicating a role for Rab38 in lung function and development (5,6). Dysfunction mutation studies implicate Rab38 in the post-Golgi trafficking of enzymes (e.g. TYRP1) related to melanogenesis and stability (7,8). Alternate Names Melanoma antigen NY-MEL-1; NY-MEL-1; Rab-related GTP-binding protein; RAB38; RAB38, member RAS oncogene family; Ras-related protein Rab-38; rrGTPbp Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 23 Source/Isotype: Rabbit IgG