{"product_id":"cst-14371s","title":"CST,  14371S, Phospho-CDK Substrate [pTPXK] (D9V5N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying . Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Phospho-CDK Substrate [pTPXK] (D9V5N) Rabbit Monoclonal Antibody (CST #14371) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPhospho-CDK Substrate [pTPXK] (D9V5N) Rabbit Monoclonal Antibody recognizes endogenous levels of proteins that are phosphorylated at threonine within the context of a TPXK motif. This antibody does not cross-react with non-phosphorylated proteins or phospho-threonine in a different context.\nSpecies Reactivity: All Species Expected\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide library containing the phospho-TPXK motif.\n\u003cb\u003eBackground\u003c\/b\u003e\nCyclin-dependent kinases (CDKs) are a family of Ser\/Thr kinases that regulate cell-cycle transition through their association and subsequent phosphorylation of substrate proteins in a proline-directed fashion. CDKs phosphorylate a serine or threonine residue within the (S\/T)PX(R\/K) consensus sequence (1-5). Cell Signaling Technology has developed antibodies to phosphorylated proline-rich motifs for broad-based discovery applications. The TPXK motif is targeted for phosphorylation by CDKs 1, 2, 4, 5, and 6 (1-5).\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: All\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800193028265,"sku":"14371S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14371s","provider":"Iright","version":"1.0","type":"link"}