{"product_id":"cst-14495s","title":"CST,  14495S, EDC3 (D2T7U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying EDC3. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, EDC3 (D2T7U) Rabbit Monoclonal Antibody (CST #14495) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nEDC3 (D2T7U) Rabbit Monoclonal Antibody recognizes endogenous levels of total EDC3 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly322 of human EDC3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nEnhancer of mRNA decapping 3 (EDC3) was originally identified from as a protein essential to mRNA decapping prior to 5'-3' mRNA degradation (1). In human cells, EDC3 is found within cytoplasmic processing (P) bodies as part of complexes that include DCP1, DCP2, EDC4\/Ge-1, and DDX6\/RCK (2). EDC3 and DCP2 interact with TTP, an activator of AU-rich-element (ARE)-mediated decay pathway, to promote decapping and degradation of ARE mRNA (2). In addition, research studies indicate that EDC3 may play a role in the premature termination of RNA polymerase II transcription (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEDC3; enhancer of mRNA decapping 3; enhancer of mRNA decapping 3 homolog; enhancer of mRNA decapping 3 homolog (S. cerevisiae); Enhancer of mRNA-decapping protein 3; FLJ21128; FLJ31777; hYjeF_N2; hYjeF_N2-15q23; LSM16; LSM16 homolog; LSM16 homolog (EDC3, S. cerevisiae); MRT50; YJDC; yjeF domain containing; YjeF domain-containing protein 1; YjeF N-terminal domain-containing protein 2; YjeF_N2; YJEFN2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 62\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797610320041,"sku":"14495S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14495s","provider":"Iright","version":"1.0","type":"link"}