{"product_id":"cst-14526t","title":"CST,  14526T, UBQLN1 (D3T7F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying UBQLN1. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, UBQLN1 (D3T7F) Rabbit Monoclonal Antibody (CST #14526) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nUBQLN1 (D3T7F) Rabbit Monoclonal Antibody recognizes endogenous levels of total UBQLN1 protein. This antibody does not cross-react with other UBQLN proteins.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human UBQLN1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nUbiquilin 1 (UBQLN1) is a ubiquitously expressed, type 2 ubiquitin like (UBL) protein that contains an amino-terminal UBL domain and a carboxy-terminal Ub-associated (UBA) domain (1). Research studies demonstrate that UBQLN1 associates with poly-Ub chains through its UBA domain, while the UBL domain participates in interactions with proteasome subunits. Evidence suggests that UBQLN1 acts as a shuttling factor during endoplasmic-reticulum-associated protein degradation (ERAD) as it transports misfolded, ubiquitinated proteins from the ER to the proteasome for subsequent degradation (2-5). Additional research studies demonstrate that the UBL domain of UBQLN1 binds UIM-containing endocytic proteins and participates in the sequestration of protein aggregates during aggresome formation (6,7). UBQLN1 regulates presenilin protein levels and is localized in neurofibrillary tangles of Alzheimer's disease-affected brains (8). Polymorphisms in the corresponding gene may be associated with a risk of Alzheimer's disease (9-11).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDA41; DSK2; FLJ90054; hPLIC-1; PLIC-1; PLIC1; Protein linking IAP with cytoskeleton 1; testicular tissue protein Li 219; ubiquilin 1; Ubiquilin-1; UBQL1; UBQLN1; UBQN; XDRP1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 66\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797610746025,"sku":"14526T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14526t","provider":"Iright","version":"1.0","type":"link"}