{"product_id":"cst-14623t","title":"CST,  14623T, Neurofibromin 1 (D7R7D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NF1. Validated for Western Blotting,Simple Western™,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, Neurofibromin 1 (D7R7D) Rabbit Monoclonal Antibody (CST #14623) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNeurofibromin 1 (D7R7D) Rabbit Monoclonal Antibody recognizes endogenous levels of total neurofibromin 1 protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro360 of human neurofibromin 1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nNeurofibromin is a Ras-specific GTPase activating protein (RasGAP), down-regulating Ras signaling (1). Studies have shown, that mutations in inhibit its activity, resulting in benign tumors such as neurofibromas, which may form along nerves throughout the body resulting in neurofibromatosis type 1 (NF1) (2). NF1 is one of the most common autosomal dominant diseases however it remains unclear how mutation of may lead to other features of NF1 (3). In addition, mutations occur in 5-10% of human sporadic malignancies such as glioblastomas, lung adenocarcinomas, melanomas, breast and ovarian cancers, and acute myeloid leukemias. Mutations in can cause resistance to therapies including chemotherapy and radiation therapy (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp686J1293; FLJ21220; neurofibromatosis 1; neurofibromatosis-related protein NF-1; Neurofibromin; neurofibromin 1; neurofibromin truncated; NF1; NFNS; truncated neurofibromin 1; VRNF; WSS\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 320\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797612581033,"sku":"14623T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14623t","provider":"Iright","version":"1.0","type":"link"}