CST, 14638S, RanBP9 (D8M8D) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying RanBP9. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, RanBP9 (D8M8D) Rabbit Monoclonal Antibody (CST #14638) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity RanBP9 (D8M8D) Rabbit Monoclonal Antibody recognizes endogenous levels of total RanBP9 protein. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His490 of human RanBP9 protein. Background RanBP9 (RanBPM) is a Ran binding protein ubiquitously expressed and highly conserved in different organisms. It is a scaffolding protein that was identified as an interacting protein of MET inducing Ras- Erk activation (1). Several domains and motifs regulate the nuclear and cytoplasmic localization of RanBP9 (2). Research studies indicate that RanBP9 might contribute to the pathogenesis of Alzheimer's Disease (AD). In addition to elevated expression levels in AD samples, this may involve interaction of RanBP9 with APP and BACE1 promoting endocytosis of APP and increased BACE1 mediated cleavage of APP to generate β-amyloid peptides (3). Alternate Names BPM-L; BPM90; novel centrosomal protein RanBPM; RAN binding protein 9; Ran Binding Protein in the Microtubule organizing center; ran binding protein, centrosomal; Ran-binding protein 9; Ran-binding protein M; RANB9; RanBP7; RANBP9; RANBPM Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 80, 91 Source/Isotype: Rabbit IgG