{"product_id":"cst-14685s","title":"CST,  14685S, MRP1\/ABCC1 (D7O8N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ABCC1. Validated for Western Blotting,Immunoprecipitation,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, MRP1\/ABCC1 (D7O8N) Rabbit Monoclonal Antibody (CST #14685) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\nImmunofluorescence (Immunocytochemistry): 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMRP1\/ABCC1 (D7O8N) Rabbit Monoclonal Antibody recognizes endogenous levels of total MRP1 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val273 of human ABCC1 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nMultidrug resistance-associated protein 1 (MRP1\/ABCC1) is a member of the MRP subfamily of ATP-binding cassette (ABC) transporters (1). MRP1\/ABCC1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agents and the glutathione (GSH) conjugates of these compounds. MRP1\/ABCC1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids, leukotrienes, and prostaglandins (2,3). Although MRP1\/ABCC1 is generally expressed in normal tissue, upregulation of MRP1\/ABCC1 has been found in a variety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer (1,4,5). Research studies show that overexpression of MRP1\/ABCC1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1\/ABCC1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1\/ABCC1 is predictive of the response and toxicity of chemotherapeutic agents in those patients (6-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nABC29; ABCC; ABCC1; ATP binding cassette subfamily C member 1; ATP-binding cassette sub-family C member 1; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex13\u0026amp;14; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1delta-ex25\u0026amp;26; ATP-binding cassette, sub-family C (CFTR\/MRP), member 1; DFNA77; DKFZp686N04233; DKFZp781G125; Glutathione-S-conjugate-translocating ATPase ABCC1; GS-X; Leukotriene C(4) transporter; LTC4 transporter; MRP; MRP1; multidrug resistance protein; Multidrug resistance-associated protein 1; multiple drug resistance protein 1; multiple drug resistance-associated protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 170-220\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797614219433,"sku":"14685S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14685s","provider":"Iright","version":"1.0","type":"link"}