{"product_id":"cst-14776s","title":"CST,  14776S, Dexamethasone","description":"Chemical Modulators for studying in the research area.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nDexamethasone is supplied as a lyophilized powder. For a 10 mM stock, reconstitute the 5 mg in 1.27 ml DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-1,000 nM for 1-24 hr.\n\u003cb\u003eStorage\u003c\/b\u003e\nStore lyophilized or in solution at -20ºC, desiccated. Protect from light. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles.\n\u003cb\u003eBackground\u003c\/b\u003e\nDexamethasone is a synthetic glucocorticoid that binds to the human glucocorticoid receptor (GR). Treatment of cells with dexamethasone leads to nuclear translocation and activation of GR. This elicits anti-inflammatory, cellular proliferation, and metabolic responses via GR-mediated transcriptional activation or repression of target genes (1-4). Research studies show that dexamethasone inhibits dendritic cell differentiation and maturation (5). The inhibition of nitric oxide synthase by dexamethasone has also been observed (6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\narrestin; corticosteroid; dexa; glucocorticoid; GR; steroid","brand":"CST","offers":[{"title":"Default Title","offer_id":46800692609193,"sku":"14776S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14776s","provider":"Iright","version":"1.0","type":"link"}