CST, 14794S, RBMX/hnRNP G (D7C2V) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying RBMX. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, RBMX/hnRNP G (D7C2V) Rabbit Monoclonal Antibody (CST #14794) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity RBMX/hnRNP G (D7C2V) Rabbit Monoclonal Antibody recognizes endogenous levels of total RBMX/hnRNP G protein. Species Reactivity: Human, Mouse, Rat, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly265 of human RBMX/hnRNP G protein. Background The X-linked RNA binding motif protein (RBMX, hnRNP G) is a multi-functional protein that is part of a heterogeneous nuclear ribonucleoprotein complex (1,2). This widely expressed protein is involved in the control of pre-mRNA splicing as part of the spliceosome. RBMX is important for the alternative splicing of many pre-mRNAs, including those that encode for dystrophin, tropomyosin, and survival motor neuron protein (SMN) in skeletal muscle and cardiac muscle (3,4). The RBMX protein is essential for the maintenance of proper sister chromatid cohesion prior to sister chromosome segregation during mitosis (5). Research studies show that RBMX accumulates at sites of DNA damage and that the presence of RBMX is required for homologous recombination repair (6). Alternate Names Glycoprotein p43; Heterogeneous nuclear ribonucleoprotein G; Heterogeneous nuclear ribonucleoprotein G, N-terminally processed; hnRNP G; hnRNP-G; HNRNPG; HNRPG; MRXS11; RBMX; RBMXP1; RBMXRT; RNA binding motif protein X-linked; RNA binding motif protein, X chromosome; RNA binding motif protein, X-linked; RNA-binding motif protein, X chromosome; RNA-binding motif protein, X chromosome, N-terminally processed; RNMX Specification REACTIVITY: H M R Mk SENSITIVITY: Endogenous MW (kDa): 42 Source/Isotype: Rabbit IgG