{"product_id":"cst-14908s","title":"CST,  14908S, SF2\/ASF (D6S7V) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SF2\/ASF. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SF2\/ASF (D6S7V) Rabbit Monoclonal Antibody (CST #14908) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSF2\/ASF (D6S7V) Rabbit Monoclonal Antibody recognizes endogenous levels of total SF2\/ASF protein.\nSpecies Reactivity: Human, Mouse, Rat, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly53 of human SF2\/ASF protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSF2\/ASF is a member of the Ser-Arg-rich (SR) protein family of highly conserved nuclear phosphoproteins involved in pre-mRNA splicing (1). Besides its role in nuclear pre-mRNA splicing, SF2\/ASF has been shown to shuttle between the nucleus and cytoplasm, suggesting additional roles in mRNA transport and cytoplasmic events (2). SF2\/ASF associates with translating ribosomes and stimulates translation (3). It also activates translation initiation by suppressing the activity of 4E-BP1, which is mediated by SF2\/ASF association with mTOR and the phosphatase PP2A (4). More recent studies have demonstrated a role for SF2\/ASF in microRNA processing (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAlternative-splicing factor 1; ASF; ASF-1; MGC5228; pre-mRNA-splicing factor SF2, P33 subunit; serine and arginine rich splicing factor 1; Serine\/arginine-rich splicing factor 1; SF2; SF2P33; SFRS1; splicing factor 2; Splicing factor, arginine\/serine-rich 1; splicing factor, arginine\/serine-rich, 30-KD, A; SR splicing factor 1; SRp30a; SRSF1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Mk\nSENSITIVITY: Endogenous\nMW (kDa): 33\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797618774185,"sku":"14908S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14908s","provider":"Iright","version":"1.0","type":"link"}