{"product_id":"cst-14949s","title":"CST,  14949S, TBC1D7 (D8K1Y) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TBC1D7. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, TBC1D7 (D8K1Y) Rabbit Monoclonal Antibody (CST #14949) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTBC1D7 (D8K1Y) Rabbit Monoclonal Antibody recognizes endogenous levels of total TBC1D7 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human TBC1D7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTBC1 domain family member 7 (TBC1D7, TBC7) belongs to a family of TBC (Tre-2\/Bub2\/Cdc16) containing proteins that function as GTPase-activating proteins (GAPs) (1,2). TBC1D7 was initially identified as a novel binding protein within the TSC1-TSC2 complex, where it was thought to associate with TSC1 (3,4). Additional research indicates that TBC1D7 is a third subunit of the TSC1-TSC2 complex that possesses Rheb-GAP activity and signals upstream of mTORC1 (5). Knockdown of TBC1D7 limits the association between TSC1 and TSC2, resulting in reduced Rheb-GAP activity and increased mTORC1 signaling (5). Mutations in the corresponding gene result in increased mTORC1 signaling, delayed autophagy, and are associated with intellectual disability (ID) and macrocrania (6,7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ncell migration-inducing protein 23; dJ257A7.3; DKFZp686N2317; FLJ32666; MGCPH; PIG51; TBC1 domain family member 7; TBC1 domain family, member 7; TBC1D7; TBC7; TBCD7; TS complex subunit 3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 30\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797619101865,"sku":"14949S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-14949s","provider":"Iright","version":"1.0","type":"link"}