{"product_id":"cst-15076s","title":"CST,  15076S, DDX41 (D3F1Z) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying DDX41. Validated for Western Blotting,Immunoprecipitation,eCLIP. Available in 2 sizes. Highly specific and rigorously validated in-house, DDX41 (D3F1Z) Rabbit Monoclonal Antibody (CST #15076) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFor more information about the RBP-eCLIP service please visit Eclipsebio .\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\neCLIP: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDDX41 (D3F1Z) Rabbit Monoclonal Antibody recognizes endogenous levels of total DDX41 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala98 of human DDX41 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe DEAD box helicase DDX41 is an antiviral protein that senses cytosolic DNA and activates the signaling adaptor STING to induce type I interferon production (1). The recognition of bacterial dinucleotides by DDX41 also leads to STING-dependent type 1 interferon production (2). Research studies demonstrate that knockdown of DDX41 attenuates poly(dA:dT)-induced IFN-β production and cyclic GMP-AMP synthase (cGAS, MB21D1) induction (3). The DDX41 protein is thought to be an initial constitutively expressed DNA sensor that activates type I interferon production and leads to cGAS amplification of type I interferon production (3). DDX41 is negatively regulated by the E3 ligase TRIM21 (4). Both germline and somatic mutations in the corresponding gene are associated with myeloid neoplasms (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2900024F02Rik; ABS; DDX41; DEAD (Asp-Glu-Ala-Asp) box polypeptide 41; DEAD box protein 41; DEAD box protein abstrakt homolog; DEAD-box helicase 41; DEAD-box protein abstrakt; MGC8828; MPLPF; Probable ATP-dependent RNA helicase DDX41; putative RNA helicase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 75\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797621756073,"sku":"15076S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15076s","provider":"Iright","version":"1.0","type":"link"}