{"product_id":"cst-15129t","title":"CST,  15129T, RGS4 (D4V1P) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RGS4. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, RGS4 (D4V1P) Rabbit Monoclonal Antibody (CST #15129) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nRGS4 (D4V1P) Rabbit Monoclonal Antibody recognizes endogenous levels of total RGS4 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human RGS4 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nRegulators of G protein signaling (RGS) are a family of about 40 proteins that determine the signaling amplitude and duration of G protein-coupled receptor signaling via modulation of the GTPase activity of G proteins (1-3). Each RGS has a distinct structure, expression pattern, and regulation, resulting in preferential interactions with receptors, G proteins, and other signaling proteins, as well as a unique function (4). Regulator of G-protein signaling 4 (RGS4) is a small RGS (23 kDa) that belongs to the R4 subfamily of heterotrimeric G-protein regulators. RGS4 contains a short amino-terminus that may be responsible for its functional specificity towards G-protein-coupled receptors, and a conserved RGS domain responsible for GAP activity (1). The RGS4 protein shares activity at both Gαq and Gαi\/o proteins (5,6). Degradation of RGS4 is regulated by opioid receptor-mediated ubiquitination following stimulation by opioid receptor agonists, such as the DAMGO synthetic opioid peptide (7). RGS4 modulates the action of morphine and other opiates (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp761F1924; MGC2124; MGC60244; regulator of G protein signaling 4; Regulator of G-protein signaling 4; regulator of G-protein signalling 4; RGP4; RGS4; schizophrenia disorder 9; SCZD9\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 25\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797624443049,"sku":"15129T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15129t","provider":"Iright","version":"1.0","type":"link"}