{"product_id":"cst-15160s","title":"CST,  15160S, VIMP (D1D1M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SELS. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, VIMP (D1D1M) Rabbit Monoclonal Antibody (CST #15160) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nVIMP (D1D1M) Rabbit Monoclonal Antibody recognizes endogenous levels of total VIMP protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys150 of human VIMP protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nVCP-interacting membrane protein (VIMP, selenoprotein S) is a putative reductase and endoplasmic reticulum (ER)-resident protein involved in the ER-associated degradation (ERAD) pathway (1,2). Research studies indicate that VIMP may play a protective role against inflammation and reduce ER-stress (3). The VIMP protein is a single-pass, transmembrane protein that recruits the cytosolic p97\/VCP AAA-ATPase and its cofactors, UFD1 and NPL4, to the ER membrane (4). An ER membrane complex containing Derlin-1 and VIMP forms a critical node in the ERAD machinery and links substrate recognition in the ER lumen with the retrotranslocation function of the p97\/VCP AAA-ATPase in the cytosol (1,4). Polymorphisms in the corresponding gene are associated with spontaneous preterm births and cardiovascular disease risk (5,6) while other studies do not support a correspondence between polymorphisms and inflammatory disorders (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAD-015; ADO15; MGC104346; MGC2553; SBBI8; Selenoprotein S; SELENOS; SELS; SEPS1; tanis; valosin-containing protein-interacting membrane protein; VCP interacting membrane selenoprotein; VCP-interacting membrane protein; VIMP\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 21\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797624770729,"sku":"15160S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15160s","provider":"Iright","version":"1.0","type":"link"}