CST, 15306S, KLF2 (E2Z1H) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying KLF2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, KLF2 (E2Z1H) Rabbit Monoclonal Antibody (CST #15306) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity KLF2 (E2Z1H) Rabbit Monoclonal Antibody recognizes endogenous levels of total KLF2 protein. Species Reactivity: Human Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu108 of human KLF2 protein. Background Krüppel-like factors (KLFs) are a family of zinc finger-containing DNA-binding transcriptional regulators that share homology with the Krüppel protein that regulates body segmentation. Seventeen mammalian KLFs have been identified so far and they regulate diverse biological processes, including development, differentiation, proliferation, growth, survival, and external stress responses. Alterations in their functions have been linked to many human diseases, including metabolic diseases and cancer (1-3). KLF2 is a key regulator in the differentiation and function of immune cells and vascular endothelial cells. KLF2 suppresses NF-κB-mediated gene expression and plays important roles in inflammatory response (4-7). Alternate Names KLF2; Krueppel-like factor 2; Kruppel like factor 2; Kruppel-like factor 2 (lung); Kruppel-like factor LKLF; LKLF; Lung krueppel-like factor; lung Kruppel-like factor; lung Kruppel-like zinc finger transcription factor Specification REACTIVITY: H SENSITIVITY: Endogenous MW (kDa): 42 Source/Isotype: Rabbit IgG