{"product_id":"cst-15333t","title":"CST,  15333T, SARS-CoV-2 Membrane Protein (E5A8A) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying Membrane Protein SARS-CoV-2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, SARS-CoV-2 Membrane Protein (E5A8A) Mouse Monoclonal Antibody (CST #15333) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSARS-CoV-2 Membrane Protein (E5A8A) Mouse Monoclonal Antibody recognizes endogenous levels of total SARS-CoV-2 membrane protein in infected cells.\nSpecies Reactivity: Virus\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly147 of SARS-CoV-2 membrane protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe cause of the COVID-19 pandemic is a novel and highly pathogenic coronavirus, termed SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). SARS-CoV-2 is a member of the Coronaviridae family of viruses (1). The genome of SARS-CoV-2 is relatively large and encodes up to 29 open reading frames (ORFs). These include ORF1a and ORF1b (further processed into 16 non-structural proteins), 9 accessory proteins, and 4 canonical structural proteins: spike (S), envelope (E), membrane (M), and nucleocapsid (N) (2). Membrane protein is transcribed and translated from nested subgenomic RNA of the SARS-CoV-2 genome. Interaction of the membrane protein with the viral nucleocapsid protein is thought to stabilize the RNA-protein complex in the virions (3). Membrane protein has also been suggested to interact with the viral spike protein, but the functional consequence of that interaction is currently unclear (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2019-nCoV membrane protein; E1 glycoprotein; M protein; Matrix glycoprotein; membrane glycoprotein; Membrane Protein; SARS-CoV-2 membrane protein; severe acute respiratory syndrome coronavirus 2 membrane glycoprotein; VME1_SARS2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: Vir\nSENSITIVITY: Endogenous\nMW (kDa): 20-30\nSource\/Isotype: Mouse IgG1 kappa","brand":"CST","offers":[{"title":"Default Title","offer_id":46800241721513,"sku":"15333T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15333t","provider":"Iright","version":"1.0","type":"link"}