{"product_id":"cst-15413t","title":"CST,  15413T, F3\/Contactin (D7D4X) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CNTN1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, F3\/Contactin (D7D4X) Rabbit Monoclonal Antibody (CST #15413) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nF3\/Contactin (D7D4X) Rabbit Monoclonal Antibody recognizes endogenous levels of total F3\/contactin protein. This antibody detects a 32 kDa protein of unknown identity in some tissue extracts.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met774 of human F3\/contactin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nF3\/contactin (CNTN, contactin 1) is a glycosylphosphatidylinositol (GPI)-anchored neural cell adhesion protein belonging to the immunglobulin protein superfamily (1). During early mammalian development, F3\/contactin is expressed in granule neuronal progenitor (GNP) cells, where it was shown to promote GNP differentiation, in part by antagonizing sonic hedgehog (SHH)-mediated proliferation (2). Biochemical studies have shown that F3\/contactin interacts with the phosphatase PTPRZ on the surface of oligodendrocyte precursor cells, an association that was shown to be essential for oligodendrocyte maturation (3). F3\/contactin expression is also abundant in post-mitotic neurons, where its functions as a neural cell adhesion protein have been suggested to play an important role in synaptic plasticity and memory (4). Although primarily associated with neuronal development and function, F3\/contactin expression has also been implicated in extra-neuronal tumorigenesis. For example, expression of F3\/contactin was detected in both primary prostate tumors, and lymph node and bone metastases, while patient tumor samples with detectable F3\/contactin expression were associated with tumor progression and reduced recurrance-free survival (5).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCNTN1; contactin 1; Contactin-1; F3; Glycoprotein gp135; GP135; MYPCN; Neural cell surface protein F3\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 140\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797626081449,"sku":"15413T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15413t","provider":"Iright","version":"1.0","type":"link"}