{"product_id":"cst-15452t","title":"CST,  15452T, SNARK\/NUAK2 (E4V4Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying NUAK2\/SNARK. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, SNARK\/NUAK2 (E4V4Q) Rabbit Monoclonal Antibody (CST #15452) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSNARK\/NUAK2 (E4V4Q) Rabbit Monoclonal Antibody recognizes endogenous levels of total SNARK\/NUAK2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human SNARK\/NUAK2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nSNARK was identified as an SNF1\/AMPK-related kinase and member of the AMPK catalytic subunit family (1,2). This enzyme was separately identified as a TNFα-induced SNF1-like kinase 2 (NUAK2) (3). The kinase activity of SNARK\/NUAK2 is increased by AMP and AICAR (1). SNARK\/NUAK2 activity is regulated by a variety of cellular stresses such as endoplasmic reticulum (ER) stress and oxidative stresses (4), suggesting that SNARK\/NUAK2 is a signaling molecule involved in the cell stress response (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDKFZp434J037; DKFZp686F01113; FLJ90349; NUAK family kinase 2; NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; NUAK2; Omphalocele kinase 2; OMPHK2; SNARK; SNF1\/AMP activated protein kinase; SNF1\/AMP kinase-related kinase\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 78\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797626507433,"sku":"15452T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15452t","provider":"Iright","version":"1.0","type":"link"}