{"product_id":"cst-15491t","title":"CST,  15491T, ANP32A (D7Z5U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ANP32A. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, ANP32A (D7Z5U) Rabbit Monoclonal Antibody (CST #15491) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:3000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nANP32A (D7Z5U) Rabbit Monoclonal Antibody recognizes endogenous levels of total ANP32A protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding the amino terminus of human ANP32A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nANP32A is the founding member of the acidic nuclear phosphoprotein 32 kDa (ANP32) family, which share two highly conserved regions: the N-terminal leucine-rich repeats (LRRs) sequence and the C-terminal acidic tail (1). ANP32A was originally purified as a potent, heat-stable protein phosphatase 2A (PP2A)-specific inhibitor, and subsequent studies suggested that it binds directly to the catalytic subunit of PP2A (2,3). ANP32A is a key component of acetyltransferase inhibitor complex that regulates chromatin remodeling and transcription (4,5). ANP32A also forms a multiunit complex with HuR that regulates RNA transport and stability (6). In addition, ANP32A is reported to play roles in apoptosis, neural differentiation and pathogenesis (7-10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nacidic (leucine-rich) nuclear phosphoprotein 32 family, member A; Acidic leucine-rich nuclear phosphoprotein 32 family member A; acidic nuclear phosphoprotein 32 family member A; Acidic nuclear phosphoprotein pp32; AN32A; ANP32A; C15orf1; cerebellar leucine rich acidic nuclear protein; epididymis secretory sperm binding protein; hepatopoietin Cn; HPPCn; I1PP2A; inhibitor-1 of protein phosphatase-2A; LANP; Leucine-rich acidic nuclear protein; MAPM; Mapmodulin; MGC119787; MGC150373; PHAP1; PHAPI; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; PP32; Putative HLA-DR-associated protein I; putative human HLA class II associated protein I\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797626572969,"sku":"15491T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15491t","provider":"Iright","version":"1.0","type":"link"}