{"product_id":"cst-15805s","title":"CST,  15805S, Mouse TGF-beta1 Recombinant Protein","description":"Growth Factors and Cytokines for studying TGFB1 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse TGF-β1 Recombinant Protein is supplied as lyophilized material that is very stable at -20ºC. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/mL which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4ºC and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mTGF-β1 was expressed in 293 cells and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nTGF-β1 activities include proliferation, angiogenesis, and promotion or inhibition of many immune events (1-3). TGF-β1 is produced by a number of cell types including regulatory T cells, fibroblasts, epithelial cells, and endothelial cells (3). TGF-β1 binds to TβRII homodimer, which then complexes with TβRI homodimer (1,4). The oligomeric receptor complex phosphorylates subsets of the SMAD proteins that then act to induce and repress a number of target genes (1,3,4). TGF-β1 binding can also activate the Erk2, p38, and JNK pathways via TAK1 (4). TGF-β1 appears to promote late stage progression and metastasis in some cancers (1,2).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800711844009,"sku":"15805S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-15805s","provider":"Iright","version":"1.0","type":"link"}