{"product_id":"cst-16743t","title":"CST,  16743T, Orexin (D6G9T) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying HCRT. Validated for Immunohistochemistry (Paraffin),Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, Orexin (D6G9T) Rabbit Monoclonal Antibody (CST #16743) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunohistochemistry (Paraffin): 1:100\nImmunofluorescence (Frozen): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunohistochemistry (Paraffin), Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nOrexin (D6G9T) Rabbit Monoclonal Antibody recognizes endogenous levels of total orexin protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the sequence of the mature human orexin protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nOrexin, also called HCRT or hypocretin, is expressed as a precursor that is processed into two biologically active neuropeptides called orexin-A (HCRT1) and orexin-B (HCRT2) (1). Orexin is expressed in the lateral and posterior hypothalamus and plays a role in feeding behavior (1). The orexin neuropeptides act by stimulating the two orexin receptors that belong to the G Protein-Coupled Receptors family (1). Orexin receptor 1 is mostly found in the hypothalamic region, while orexin receptor 2 is also found in the cerebral cortex and the nucleus accumbent (2). Orexin also plays a role in adipocyte homeostasis and is required for brown adipose tissue development, differentiation, and function (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHCRT; Hcrt1; Hcrt2; hypocretin; hypocretin (orexin) neuropeptide; hypocretin (orexin) neuropeptide precursor; Hypocretin neuropeptide precursor; Hypocretin-1; Hypocretin-2; NRCLP1; OREX; Orexin; Orexin-A; Orexin-B; OX; PPORX; PPOX; prepro-orexin\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous (IHC-P, IF-F), Transfected (W)\nMW (kDa): 16\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800276029609,"sku":"16743T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-16743t","provider":"Iright","version":"1.0","type":"link"}