{"product_id":"cst-16810s","title":"CST,  16810S, CaMKK2 (D8D4D) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CaMKK2. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CaMKK2 (D8D4D) Rabbit Monoclonal Antibody (CST #16810) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCaMKK2 (D8D4D) Rabbit Monoclonal Antibody recognizes endogenous levels of total CaMKK2 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly228 of human CaMKK2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCalcium\/Calmodulin-dependent Protein Kinase Kinase 2 (CaMKK2) is a member of the CaMK family that contains a central Ser\/Thr kinase domain followed by a regulatory domain consisting of overlapping autoinhibitory and CaM-binding regions (1). CaMKK2 can be distinguished from other CaMK family members by the presence of a unique Pro\/Arg\/Gly-rich insert following the ATP-binding domain (2). CaMKK2 phosphorylates CaMKI at Thr177 and CaMKIV at Thr200 (3). CaMKK2 also phosphorylates AMPKα in response to calcium (4). CaMKK2 has been implicated in long-term memory formation (5) and adipocyte development (6). CaMKK2 is phosphorylated at Ser511 by death-associated protein kinase (DAPK) in a signaling cascade thought to be involved in neuronal death (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ncalcium\/calmodulin dependent protein kinase kinase 2; calcium\/calmodulin-dependent protein kinase beta; Calcium\/calmodulin-dependent protein kinase kinase 2; calcium\/calmodulin-dependent protein kinase kinase 2, beta; Calcium\/calmodulin-dependent protein kinase kinase beta; CaM-kinase kinase 2; CaM-kinase kinase beta; CaM-KK 2; CaM-KK beta; CAMKK; CaMKK 2; CaMKK beta; CAMKK beta protein; CAMKK2; CAMKKB; KIAA0787; KKCC2; MGC15254\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 68, 70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797631422633,"sku":"16810S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-16810s","provider":"Iright","version":"1.0","type":"link"}