{"product_id":"cst-16990s","title":"CST,  16990S, PCGF2 (F9G6A) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PCGF2. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, PCGF2 (F9G6A) Rabbit Monoclonal Antibody (CST #16990) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPCGF2 (F9G6A) Rabbit Monoclonal Antibody recognizes endogenous levels of total PCGF2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly140 of human PCGF2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nPolycomb group RING finger homologs (PCGF1-6) are essential proteins for the assembly of the polycomb repressive complex 1 (PRC1) group of complexes. RING1A\/B and a unique PCGF protein make up the catalytic core of PRC1 to ubiquitinate histone H2A. Differences in binding specificities give PRC1 complexes unique functions, depending on which PCGF is included (1-3). Polycomb group RING finger protein 2 (PCGF2), also known as Mel-18, is widely expressed in human tissues and primarily functions as a transcriptional repressor. This protein is broadly expressed in human tissues and has been implicated in numerous regulatory pathways that include cell proliferation and senescence, X chromosome inactivation, embryogenesis, hematopoiesis, and tumor suppression (4-10). Furthermore, this protein is known to harbor posttranslational modifications, including phosphorylation and ubiquitination, and is also reported to dimerize (11,12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nDNA-binding protein Mel-18; MEL-18; MEL18; MGC10545; PCGF2; polycomb group ring finger 2; Polycomb group RING finger protein 2; RING finger protein 110; RNF110; TPFS; Zinc finger protein 144; ZNF144\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 50, 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797632012457,"sku":"16990S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-16990s","provider":"Iright","version":"1.0","type":"link"}