CST, 17206T, METTL7B (F6K2W) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying METTL7B. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, METTL7B (F6K2W) Rabbit Monoclonal Antibody (CST #17206) is ready to ship. Product Usage Information Western Blotting: 1:1000 Immunoprecipitation: 1:100 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting, Immunoprecipitation Specificity / Sensitivity METTL7B (F6K2W) Rabbit Monoclonal Antibody recognizes endogenous levels of total METTL7B protein. This antibody does not cross-react with METTL7A protein. Species Reactivity: Human, Monkey Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro236 of human METTL7B protein. Background Methyltransferase-like protein 7B (METTL7B), also known as thiol methyltransferase 1B (TMT1B), is part of the METTL family of methyltransferases. METTL7B catalyzes the transfer of a methyl group from S-adenosyl-L-methionine (AdoMet) to alkyl thiol molecules (1,2). METTL7B is found in the Golgi and endoplasmic reticulum, where it is involved in the inhibition of harmful lipid accumulation (2-5). High expression of METTL7B protein has been shown in various cancer types. In gliomas, METTL7B inhibits EGR1 expression to drive progression (6,7). METTL7B is also highly expressed in lung cancers and can drive tumorigenesis (8,9). In acute lymphoblastic leukemia, METTL7B enzymatic activity has been shown to be a critical component in glycolysis, affecting cell growth (10). Alternate Names ALDI; associated with lipid droplets 1; MET7B; methyltransferase like 7B; Methyltransferase-like protein 7B; METTL7B; MGC17301; thiol methyltransferase 1B; Thiol S-methyltransferase METTL7B; Thiol S-methyltransferase TMT1B; TMT1B Specification REACTIVITY: H Mk SENSITIVITY: Endogenous MW (kDa): 24 Source/Isotype: Rabbit IgG