{"product_id":"cst-17402s","title":"CST,  17402S, Nectin-4\/PVRL4 Antibody","description":"Polyclonal Antibody for studying Nectin 4. Validated for Western Blotting. Highly specific and rigorously validated in-house, Nectin-4\/PVRL4 Antibody (CST #17402) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nNectin-4\/PVRL4 Antibody recognizes endogenous levels of total Nectin-4\/PVRL4 protein. Based upon sequence alignment, this antibody is not predicted to cross-react with PVR, PVRL1, PVRL2, and PVRL3 proteins.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human Nectin-4\/PVRL4 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nNectin-4\/poliovirus receptor-related 4 (PVRL4) is a type-I transmembrane glycoprotein that belongs to the immunoglobulin superfamily and promotes cell-cell adhesion by serving as a major component of adherens junctions (1-3). The extracellular domain of Nectin-4, which contains an Ig variable-like domain (V) and two Ig constant-like domains (C), mediates binding to the measles virus (4) and to neighboring cells through heterophilic interactions with Nectin-1 (5,6). Unlike other nectin family members, which are widely expressed in adult tissues, Nectin-4 expression in humans is largely restricted to the placenta (7). Research studies have demonstrated that Nectin-4 is overexpressed in a variety of human solid tumors of the pancreas (8), breast (9,10), lung (11), and ovary (12). Due to its restricted expression pattern in normal human tissues, Nectin-4 may serve as a novel diagnostic and therapeutic target for a variety of human tumors.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEDSS1; Ig superfamily receptor LNIR; LNIR; NECT4; nectin 4; Nectin cell adhesion molecule 4; Nectin-4; NECTIN4; poliovirus receptor-related 4; Poliovirus receptor-related protein 4; Processed poliovirus receptor-related protein 4; PRR4; PVRL4\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 62, 75\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797633880233,"sku":"17402S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-17402s","provider":"Iright","version":"1.0","type":"link"}