{"product_id":"cst-17433s","title":"CST,  17433S, CMTM4 Antibody","description":"Polyclonal Antibody for studying CMTM4. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, CMTM4 Antibody (CST #17433) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCMTM4 Antibody recognizes endogenous levels of total CMTM4 protein. This antibody does not cross-react with CMTM6 protein.\nSpecies Reactivity: Human, Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu202 of human CMTM4 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nCKLF-like MARVEL transmembrane domain-containing protein 4 (CMTM4) is a member of the chemokine-like factor (CKLF)-like MARVEL transmembrane domain-containing family (1). CMTM4 acts as a tumor suppressor in various malignancies, and regulates cell growth and transition through the cell cycle in HeLa cells (1-4). CMTM4Â plays an important role in angiogenesis, enabling internalization of membrane-bound vascular endothelial cadherin at adherens junctions, mediating endothelial barrier function, and controlling vascular sprouting (5). In the immune system, CMTM4 acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1, an immune inhibitory ligand critical for immune tolerance to self and anti-tumor immunity (6-8). CMTM4 may also protect PD-L1 from being polyubiquitinated and targeted for degradation (8). Due to the roles of CMTM4 in the immune system and as a tumor suppressor, it is being investigated as a therapeutic target for the treatment of cancer.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nchemokine-like factor super family 4; Chemokine-like factor superfamily member 4; CKLF like MARVEL transmembrane domain containing 4; CKLF-like MARVEL transmembrane domain containing 4; CKLF-like MARVEL transmembrane domain-containing protein 4; CKLF4; CKLFSF4; CMTM4\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M\nSENSITIVITY: Endogenous\nMW (kDa): 22\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797633913001,"sku":"17433S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-17433s","provider":"Iright","version":"1.0","type":"link"}