{"product_id":"cst-17843s","title":"CST,  17843S, TPPP\/p25 (E9C8G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TPPP mouse. Validated for Immunofluorescence (Frozen). Available in 2 sizes. Highly specific and rigorously validated in-house, TPPP\/p25 (E9C8G) Rabbit Monoclonal Antibody (CST #17843) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nImmunofluorescence (Frozen): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Immunofluorescence (Frozen)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTPPP\/p25 (E9C8G) Rabbit Monoclonal Antibody recognizes endogenous levels of total TPPP\/p25 protein. Nonspecific labeling of the epithelium of fixed frozen mouse colon has been observed by immunofluorescence.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse TPPP\/p25 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nTubulin polymerization-promoting protein (TPPP, also known as p25) is a microtubule nucleation factor in oligodendrocytes. As a largely unstructured protein, TPPP\/p25 induces microtubule polymerization (1,2). TPPP\/p25 is enriched in oligodendrocytes in the brain and may play a unique role in the structure and function of these unique cells (3,4). Oligodendrocytes extend elaborate microtubule arbors that contact neuronal axon segments to generate a myelin sheath that is critical for proper propagation of axonal action potentials. TPPP\/p25 may not only play a critical role in establishing the microtubule network for oligodendrocytes, but may also contribute to the generation of Golgi outposts, which are Golgi found outside of the cell body. Golgi outposts may play a specialized role in building the local cytoarchitecture of oligodendrocytes and other brain cells (5,6). Misregulation of TPPP\/p25 is linked to several neurodegenerative diseases, including Parkinson's disease, and may contribute to disease etiology and\/or represent a potential therapeutic target (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n25 kDa brain-specific protein; 2900041A09Rik; AI849835; brain-specific protein p25 alpha; p25-alpha; TPPP; TPPP\/p25; tubulin polymerization promoting protein; Tubulin polymerization-promoting protein\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800291823785,"sku":"17843S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-17843s","provider":"Iright","version":"1.0","type":"link"}