{"product_id":"cst-17853t","title":"CST,  17853T, beta1-Adrenergic Receptor (F1S8F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying adrenergic receptor beta-1. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, beta1-Adrenergic Receptor (F1S8F) Rabbit Monoclonal Antibody (CST #17853) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nβ1-Adrenergic Receptor (F1S8F) Rabbit mAb recognizes endogenous levels of total β1-adrenergic receptor protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human β1-adrenegric receptor protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nβ1-Adrenergic Receptor (β1AR) is a G protein-coupled receptor (GPCR) involved in the regulation of cardiovascular functions (1). Together with β2AR, β1AR is a major βAR in the heart. β1AR is activated by catecholamines and couples to Gα protein, activating adenylate cyclase and increasing intracellular cAMP levels (2). Beta-blockers (βAR antagonists), one of the major class of therapeutics in cardiovascular medicine, act mostly by preventing catecholamine binding to β1AR (3).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nADRB1; ADRB1R; adrenergic, beta-1-, receptor; adrenoceptor beta 1; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoceptor; Beta-1 adrenoreceptor; BETA1AR; FNSS2; RHR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 51-70\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797635420329,"sku":"17853T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-17853t","provider":"Iright","version":"1.0","type":"link"}