{"product_id":"cst-19360t","title":"CST,  19360T, PGLYRP-1\/PGRP-S (E3B6M) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying PGLYRP1. Validated for Flow Cytometry (Fixed\/Permeabilized). Available in 2 sizes. Highly specific and rigorously validated in-house, PGLYRP-1\/PGRP-S (E3B6M) Rabbit Monoclonal Antibody (CST #19360) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Fixed\/Permeabilized): 1:100 - 1:400\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Fixed\/Permeabilized)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nPGLYRP-1\/PGRP-S (E3B6M) Rabbit Monoclonal Antibody recognizes endogenous levels of total PGLYRP-1\/PGRP-S protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human PGLYRP-1\/PGRP-S protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThe human peptidoglycan recognition protein (PGRP) family is composed of four independent genes named for the relative length of their translated product. Human PGRP family proteins are soluble pattern-recognition receptors of the innate immune response that bind peptidoglycan and Gram-positive bacteria, and have direct bactericidal activity (1,2). PGRP-short (PGRP-S), also known as PGLYRP-1 and Tag7, is 196 amino acids (aa) in length (3). PGLYRP-1\/PGRP-S is a secreted glycoprotein expressed by neutrophils that participates in killing phagocytized bacteria (4,5). PGLYRP-1\/PGRP-S also has been shown to form a stable cytotoxic complex with the heat shock protein Hsp70 to induce tumor cell death (6,7). PGRP-long (PGRP-L), also known as PGLYRP-2, is 576 aa long. PGLYRP-2\/PGRP-L is an N-acetylmuramoyl-L-alanine amidase that hydrolyzes bacterial peptidoglycan (8,9). PGRP-intermediate alpha, also known as PGLYRP-3, and PGRP-intermediate beta, also known as PGLYRP-4, are 341 aa and 373 aa long, respectively. PGLYRP-3 and PGLYRP-4 are co-expressed in the same cells and are exclusively secreted as homo- or heterodimers with antibacterial function (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nMGC126894; MGC126896; Peptidoglycan recognition protein 1; Peptidoglycan recognition protein short; PGLYRP; PGLYRP1; PGRP; PGRP-S; PGRP1; PGRPS; TAG7; TNF superfamily, member 3 (LTB)-like (peptidoglycan recognition protein); TNFSF3L\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800290578601,"sku":"19360T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19360t","provider":"Iright","version":"1.0","type":"link"}