CST, 19394S, ICAM-5 (F6E2B) Rabbit Monoclonal Antibody

Monoclonal Antibody for studying ICAM5. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, ICAM-5 (F6E2B) Rabbit Monoclonal Antibody (CST #19394) is ready to ship. Product Usage Information Western Blotting: 1:1000 Simple Western™: 1:10 - 1:50 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity ICAM-5 (F6E2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total ICAM-5 and sICAM-5 protein. This antibody detects a 70 kDa protein of unknown identity in some cell lines. Species Reactivity: Human, Mouse, Rat Source / Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro40 of human ICAM-5 protein. Background Intercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is a type I membrane glycoprotein expressed on the surface of telencephalic neurons in the brain that plays a role in neuronal adhesion, signal transmission, and neurite outgrowth (1). ICAM-5 contains nine immunoglobulin-like domains in its extracellular region, which interact with integrins and ERM-family proteins, facilitating the formation of functional synapses and dendritic filopodia, respectively (2,3). This extracellular region has also been shown to be cleaved, forming a soluble ICAM-5 fragment implicated in the immune system, potentially playing a neuroprotective role in neurodegeneration (4-6). Alternate Names ICAM-5; ICAM5; Intercellular adhesion molecule 5; intercellular adhesion molecule 5, telencephalin; Telencephalin; TLCN; TLN Specification REACTIVITY: H M R SENSITIVITY: Endogenous MW (kDa): 140, 100 Source/Isotype: Rabbit IgG