{"product_id":"cst-19394s","title":"CST,  19394S, ICAM-5 (F6E2B) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ICAM5. Validated for Western Blotting,Simple Western™. Available in 2 sizes. Highly specific and rigorously validated in-house, ICAM-5 (F6E2B) Rabbit Monoclonal Antibody (CST #19394) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nICAM-5 (F6E2B) Rabbit Monoclonal Antibody recognizes endogenous levels of total ICAM-5 and sICAM-5 protein. This antibody detects a 70 kDa protein of unknown identity in some cell lines.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro40 of human ICAM-5 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntercellular adhesion molecule-5 (ICAM-5), also known as telencephalin, is a type I membrane glycoprotein expressed on the surface of telencephalic neurons in the brain that plays a role in neuronal adhesion, signal transmission, and neurite outgrowth (1). ICAM-5 contains nine immunoglobulin-like domains in its extracellular region, which interact with integrins and ERM-family proteins, facilitating the formation of functional synapses and dendritic filopodia, respectively (2,3). This extracellular region has also been shown to be cleaved, forming a soluble ICAM-5 fragment implicated in the immune system, potentially playing a neuroprotective role in neurodegeneration (4-6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nICAM-5; ICAM5; Intercellular adhesion molecule 5; intercellular adhesion molecule 5, telencephalin; Telencephalin; TLCN; TLN\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 140, 100\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797641318569,"sku":"19394S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19394s","provider":"Iright","version":"1.0","type":"link"}