{"product_id":"cst-19472s","title":"CST,  19472S, Cyclin K (E7F4N) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Cyclin K. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, Cyclin K (E7F4N) Rabbit Monoclonal Antibody (CST #19472) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCyclin K (E7F4N) Rabbit Monoclonal Antibody recognizes endogenous levels of total cyclin K protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala15 of human cyclin K protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCyclin K is a positive regulator of transcriptional cyclin-dependent kinases (CDKs) CDK12 and CDK13. The cyclin K\/CDK12 complex regulates the formation of the pre-replicative complex during G1 phase of the cell cycle (1), as well as the expression of key proteins in the DNA Damage Response (DDR) (2). Regulation of DDR-related gene expression involves cyclin K interaction with the histone methyltransferase SETD1A (3). Due to its importance in maintaining genome stability through regulation of the DDR, the cyclin K\/CDK12 complex is an emerging therapeutic target in human cancer (4,5). Targeted protein degradation via molecular glues and PROTACs have been employed to specifically degrade cyclin K\/CDK12 as a means of targeting the DDR in human cancer (6-9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCCNK; CPR4; cyclin K; Cyclin-K; IDDHDF; MGC9113\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 79\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797641810089,"sku":"19472S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19472s","provider":"Iright","version":"1.0","type":"link"}