{"product_id":"cst-19582t","title":"CST,  19582T, TSLPR\/CRLF2 (F3K9G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CRLF2. Validated for WB,IP,F,F. Available in 2 sizes. Highly specific and rigorously validated in-house, TSLPR\/CRLF2 (F3K9G) Rabbit Monoclonal Antibody (CST #19582) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\nFlow Cytometry (Fixed\/Permeabilized): 1:200 - 1:800\nFlow Cytometry (Live): 1:200 - 1:800\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation, Flow Cytometry (Fixed\/Permeabilized), Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTSLPR\/CRLF2 (F3K9G) Rabbit Monoclonal Antibody recognizes endogenous levels of total TSLPR\/CRLF2 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of human TSLPR\/CRLF2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nThymic stromal lymphopoietin (TSLP) is a cytokine produced by epithelial cells at barrier surfaces and granulocytes (1). TSLP acts on dendritic cells, lymphocytes, and granulocytes by binding to a heterodimer composed of TSLPR (TSLP receptor; also known as cytokine receptor-like factor 2 or CRLF2) and IL-7Rα (2-5). Activation of this heterodimer further activates the Jak\/Stat signaling pathway and stimulates cellular proliferation (6-8). TSLPR\/CRLF2 overexpression is linked to leukemia, where it is identified in 5-15% of all cases of B-cell acute lymphoblastic leukemia (B-ALL) and is the most common hallmark of the Philadelphia chromosome (Ph)-like B-ALL subtype (8-11). This overexpression is associated with poor clinical outcome, and TSLPR\/CRLF2 is increasingly being studied as a target for B-ALL immunotherapies (12,13).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nCRL2; CRLF2; CRLF2Y; cytokine receptor CRL2; cytokine receptor CRL2 precusor; cytokine receptor like factor 2; Cytokine receptor-like 2; Cytokine receptor-like factor 2; IL-XR; ILXR; P2RY8\/CRLF2 fusion partner; Thymic stromal lymphopoietin protein receptor; thymic stromal lymphopoietin receptor; thymic stromal-derived lymphopoietin receptor; TSLP receptor; TSLPR\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797642006697,"sku":"19582T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19582t","provider":"Iright","version":"1.0","type":"link"}