{"product_id":"cst-19607s","title":"CST,  19607S, MEKK2 Antibody","description":"Polyclonal Antibody for studying MEKK2. Validated for Western Blotting,Immunoprecipitation. Highly specific and rigorously validated in-house, MEKK2 Antibody (CST #19607) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nMEKK2 Antibody recognizes endogenous levels of total MEKK2 protein. This antibody does not cross-react with MEKK3 protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly292 of human MEKK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nMitogen-activated protein kinase kinase kinase 2 (MEKK2\/MAP3K2) belongs to the MAP3K family of Ser\/Thr kinases. Research studies have demonstrated that MEKK2 plays a pivotal role in transducing mitogenic signals emanating from EGFR and FGF2R to JNK and ERK5 signaling cascades (1,2). Post-translationally, MEKK2 is regulated through multiple mechanisms, including dimerization (3,4), ubiquitination (5,6), phosphorylation (7), and methylation (8). Research studies implicate dysregulation of MEKK2 signaling in breast carcinoma (9), colorectal carcinoma (10), and pancreatic ductal adenocarcinoma (8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nM3K2; MAP\/ERK kinase kinase 2; MAP3K2; MAPK\/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2; MEKK2B; Mitogen-activated protein kinase kinase kinase 2\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 78\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797641973929,"sku":"19607S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19607s","provider":"Iright","version":"1.0","type":"link"}