{"product_id":"cst-19901t","title":"CST,  19901T, ATL3 (F5T5J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying ATL3. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, ATL3 (F5T5J) Rabbit Monoclonal Antibody (CST #19901) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nATL3 (F5T5J) Rabbit Monoclonal Antibody recognizes endogenous levels of total ATL3 protein.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly519 of human ATL3 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nAtlastin-3 (ATL3) is a dynamin-like, integral membrane GTPase that is localized to the endoplasmic reticulum (ER) membrane and critical for ER morphogenesis and tubular network biogenesis (1-3). ATL3 also functions as a cargo receptor for ER-phagy and promotes tubular ER degradation by specifically binding to GABARAP subfamily proteins. This ATL3-GABARAP interaction is essential for ATL3 to function in ER-phagy (4). Mutant ATL3 proteins are associated with hereditary sensory and autonomic neuropathies, illustrating the dependence of long-term sensory neuronal maintenance on the structural organization of the ER (5,6). Zika and coronavirus have been shown to modulate ER-phagy to drive viral replication by hijacking ATL3 and other ER-phagy receptors (7,8).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nATL3; ATLA3; atlastin 3; atlastin GTPase 3; Atlastin-3; DKFZp564J0863; HSN1F\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 60\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797642825897,"sku":"19901T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19901t","provider":"Iright","version":"1.0","type":"link"}