{"product_id":"cst-19912s","title":"CST,  19912S, Mouse IGF-I Recombinant Protein","description":"Growth Factors and Cytokines for studying IGF1 mouse in the research area.\n\n\u003cb\u003eStorage\u003c\/b\u003e\nMouse IGF-I Recombinant Protein is supplied as lyophilized material that is very stable at -20°C. It is recommended to reconstitute with sterile water at a concentration of 0.1 mg\/ml which can be further diluted in aqueous solutions as needed. Addition of a carrier protein (0.1% HSA or BSA) is recommended for long-term storage. Once in solution, store at 4°C and use within 1 month, or store at -20ºC to -80ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze\/thaw cycles if storing reconstituted material at -20ºC to -80ºC.\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nRecombinant mouse IGF-I was expressed in and is supplied in a lyophilized form.\n\u003cb\u003eBackground\u003c\/b\u003e\nMost circulating endocrine-acting insulin-like growth factor I (IGF-I) is produced by hepatocytes, and paracrine- or autocrine-acting IGF-I is produced by defined cell types within specific tissues (1,2). Many neoplastic cells produce IGF-I, which regulates a number of cellular processes, including energy metabolism, proliferation, and cell survival (3,4). IGF-I activity is regulated by one or more of the six extracellular IGF-binding proteins (IGFBPs). IGFBPs bind to IGF-I, and most inhibit binding between IGF-I and the IGF-I receptor (IGFIR) (1,2). Some IGFBPs may increase cell responses to IGF-I. Binding of IGF-I to IGFIR activates the Akt, JNK, and Erk pathways (2). IGF-I and IGFIR are frequently expressed by cancer cells and may contribute to the proliferation and viability of a number of cancer types (1,2).","brand":"CST","offers":[{"title":"Default Title","offer_id":46800712040617,"sku":"19912S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-19912s","provider":"Iright","version":"1.0","type":"link"}