{"product_id":"cst-2036t","title":"CST,  2036T, Cleaved Lamin A (Small Subunit) (30H5) Mouse Monoclonal Antibody","description":"Monoclonal Antibody for studying Lamin A\/C (small subunit) cleaved. Validated for Western Blotting,Immunofluorescence (Immunocytochemistry). Available in 2 sizes. Highly specific and rigorously validated in-house, Cleaved Lamin A (Small Subunit) (30H5) Mouse Monoclonal Antibody (CST #2036) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunofluorescence (Immunocytochemistry): 1:100\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunofluorescence (Immunocytochemistry)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCleaved Lamin A (Small Subunit) (30H5) Mouse Monoclonal Antibody detects endogenous levels of the small fragment of lamin A (and lamin C) resulting from cleavage at aspartic acid 230. This antibody does not cross-react with full length lamin A or C.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino-terminal residues surrounding Asp230 of human lamin A.\n\u003cb\u003eBackground\u003c\/b\u003e\nLamins are nuclear membrane structural components that are important in maintaining normal cell functions such as cell cycle control, DNA replication, and chromatin organization (1-3). Lamin A\/C is cleaved by caspase-6 and serves as a marker for caspase-6 activation. During apoptosis, lamin A\/C is specifically cleaved into a large (41-50 kDa) and a small (28 kDa) fragment (3,4). The cleavage of lamins results in nuclear dysregulation and cell death (5,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n70 kDa lamin; CDCD1; CDDC; CMD1A; CMT2B1; EMD2; epididymis secretory sperm binding protein; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin A\/C; lamin A\/C-like 1; Lamin-A\/C; LDP1; LFP; LGMD1B; LMN1; LMNA; LMNC; LMNL1; MADA; mandibuloacral dysplasia type A; Prelamin-A\/C; PRO1; Renal carcinoma antigen NY-REN-32\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 28\nSource\/Isotype: Mouse IgG1","brand":"CST","offers":[{"title":"Default Title","offer_id":46797650657449,"sku":"2036T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2036t","provider":"Iright","version":"1.0","type":"link"}