{"product_id":"cst-20488t","title":"CST,  20488T, Integrin beta 2 (E2Z7F) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying Integrin Beta2 mouse. Validated for Flow Cytometry (Live). Available in 2 sizes. Highly specific and rigorously validated in-house, Integrin beta 2 (E2Z7F) Rabbit Monoclonal Antibody (CST #20488) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nFlow Cytometry (Live): 1:50 - 1:200\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Flow Cytometry (Live)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIntegrin beta 2 (E2Z7F) Rabbit Monoclonal Antibody recognizes endogenous levels of total integrin beta 2 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro101 of mouse integrin beta 2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nIntegrins are transmembrane glycoproteins that form heterodimers consisting of one α and one β subunit. Integrin dimers act as receptors for extracellular matrix proteins and cell-surface ligands. Integrin signaling to (inside-out) and from (outside-in) extracellular molecules regulates multiple cellular processes, such as development, wound healing, immune response, invasion, metastasis, and angiogenesis (1,2). Integrin β2 (CD18) is the β subunit of the leukocyte-specific integrin family. Leukocyte integrins include Integrin β2 (CD18)\/αL (CD11a) (LFA-1, lymphocyte function associated antigen 1), Integrin β2 (CD18)\/αM (CD11b) (Mac-1), Integrin β2 (CD18)\/αX (CD11c), and Integrin β2 (CD18)\/αD (CD11d). These integrins bind to immunoglobulin superfamily members, such as ICAM-1 and VCAM-1 on endothelial cells, to mediate firm adhesion and transendothelial migration of leukocytes (3). Integrin β2 (CD18) deficiency results in LAD (leukocyte adhesion deficiency), a disease characterized by impairment of leukocyte recruitment, resulting in an inability to fight infection (4).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\n2E6; AI528527; Cd18; Cell surface adhesion glycoproteins LFA-1\/CR3\/p150,95 subunit beta; Complement receptor C3 subunit beta; integrin beta 2; Integrin beta-2; ITB2; Itgb2; LAD; LCAMB; Lfa1; lymphocyte function associated antigen 1; Mac-1 beta; macrophage antigen-1 beta; MF17; OTTMUSP00000021575\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46800330326185,"sku":"20488T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-20488t","provider":"Iright","version":"1.0","type":"link"}