CST, 2076S, TMP21 Antibody

Polyclonal Antibody for studying TMP21. Validated for Western Blotting. Highly specific and rigorously validated in-house, TMP21 Antibody (CST #2076) is ready to ship. Product Usage Information Western Blotting: 1:1000 Storage Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody. Protocol Available protocols: Western Blotting Specificity / Sensitivity TMP21 Antibody detects endogenous levels of total TMP21 protein. Species Reactivity: Human, Mouse, Monkey Source / Purification Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues of human TMP21. Antibodies are purified by protein A and peptide affinity chromatography. Background TMP21, a type I transmembrane protein, is a member of the p24 cargo protein family, which is highly enriched in the ER, the Golgi and coat protein (COP) I and II transport vesicles (1,2). TMP21 is involved in protein transport and vesicular targeting. In particular, TMP21 influences APP trafficking by stabilizing nascent APP. The absence of TMP21 leads to enhanced maturation and cell surface accumulation of APP (3). In addition, TMP21 is a non-essential component of the γ-secretase complex with the potential to modulate γ-secretase mediated cleavage and Aβ production without having an effect on ε-secretase activity (4). Alternate Names 21 kDa transmembrane trafficking protein; 21 kDa transmembrane-trafficking protein; p23; p24 family protein delta-1; P24(DELTA); p24d1; p24delta; p24delta1; S31I125; S31III125; testicular tissue protein Li 206; TMED10; TMEDA; Tmp-21-I; TMP21; Transmembrane emp24 domain-containing protein 10; transmembrane emp24-like trafficking protein 10; transmembrane emp24-like trafficking protein 10 (yeast); transmembrane p24 trafficking protein 10; Transmembrane protein Tmp21 Specification REACTIVITY: H M Mk SENSITIVITY: Endogenous MW (kDa): 19 SOURCE: Rabbit