{"product_id":"cst-2093s","title":"CST,  2093S, SCF (C19H6) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying SCF. Validated for Western Blotting,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, SCF (C19H6) Rabbit Monoclonal Antibody (CST #2093) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunohistochemistry (Paraffin): 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nSCF (C19H6) Rabbit Monoclonal Antibody detects endogenous levels of SCF by immunohistochemical staining and by flow cytometry. Western blotting detects recombinant SCF.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to amino acids in the N-terminal sequence of human SCF.\n\u003cb\u003eBackground\u003c\/b\u003e\nStem cell factor (SCF) is a growth factor that is essential for hematopoiesis, melanogenesis and fertility. SCF is also known as mast cell growth factor (MCGF), steel factor (SLF), or kit ligand (KL) (1-3). SCF mediates its biological effects by binding to and activating c-Kit (4). SCF induces dimerization of c-Kit followed by trans-autophosphorylation of the cytoplasmic protein tyrosine kinase domain, leading to subsequent recruitment of signaling proteins, tyrosine phosphorylation of substrates, and activation of multiple signaling pathways (5,6). SCF\/c-Kit may take part in the growth control of human malignancies (7).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nc-Kit ligand; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Kit ligand; Kitl; KITLG; KL-1; Mast cell growth factor; MGF; SCF; SF; SHEP7; sKITLG; SLF; Soluble KIT ligand; steel factor; Stem cell factor\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 18\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797654884521,"sku":"2093S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2093s","provider":"Iright","version":"1.0","type":"link"}