{"product_id":"cst-2293s","title":"CST,  2293S, IQGAP1 Antibody","description":"Polyclonal Antibody for studying IQGAP1. Validated for Western Blotting. Highly specific and rigorously validated in-house, IQGAP1 Antibody (CST #2293) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nIQGAP1 Antibody detects endogenous levels of total IQGAP1 protein. This antibody may cross-react with a 35kDa protein of unknown origin.\nSpecies Reactivity: Human, Mouse, Rat, Hamster, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IQGAP1.\n\u003cb\u003eBackground\u003c\/b\u003e\nIQGAPs are scaffolding proteins involved in mediating cytoskeletal function. They contain multiple protein interaction domains and bind to a growing number of molecules including actin, myosin light chain, calmodulin, E-cadherin, and β-catenin (reviewed in 1). Through their GAP-related domains, they bind the small GTPases Rac1 and cdc42. IQGAPs lack GAP activity, however, and regulate small GTPases by stabilizing their GTP-bound (active) forms (2,3). Research studies have shown that the function and distribution of the IQGAP proteins widely vary. IQGAP1 is ubiquitously expressed and has been found to interact with APC (4) and the CLIP170 complex (5) in response to small GTPases, promoting cell polarization and migration. Additional research studies have suggested that IQGAP1 could play a part in the invasiveness of some cancers (6-8). IQGAP2, which is about 60% identical to IQGAP1, is expressed primarily in liver (3), but lower levels have been detected in the prostate, kidney, thyroid, stomach, and testis (9,10). Research studies have shown that IQGAP2 displays tumor suppressor properties (7). Less is known about the function of IQGAP3, but this protein is present in the lung, brain, small intestine, and testis (9) and is only expressed in proliferating cells (11), suggesting a role in cell growth and division.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nHUMORFA01; IQ motif containing GTPase activating protein 1; IQGA1; IQGAP1; KIAA0051; p195; Ras GTPase-activating-like protein IQGAP1; RasGAP-like with IQ motifs; SAR1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R Hm Mk\nSENSITIVITY: Endogenous\nMW (kDa): 195\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46797663076521,"sku":"2293S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-2293s","provider":"Iright","version":"1.0","type":"link"}