{"product_id":"cst-23042s","title":"CST,  23042S, Dectin-1\/Clec7a Antibody","description":"Polyclonal Antibody for studying dectin-1 mouse. Validated for Western Blotting. Highly specific and rigorously validated in-house, Dectin-1\/Clec7a Antibody (CST #23042) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, and 50% glycerol. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nDectin-1\/Clec7a Antibody recognizes endogenous levels of total Dectin-1 protein.\nSpecies Reactivity: Mouse\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nPolyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding His26 of mouse Dectin-1 protein. Antibodies are purified by peptide affinity chromatography.\n\u003cb\u003eBackground\u003c\/b\u003e\nDectin-1, also known as Clec7a, is a C-type lectin receptor expressed by macrophages, monocytes, dendritic cells, neutrophils, and a subset of γδ T cells (1,2). Dectin-1 is a glycoprotein with eight different isoforms, generated through alternative splicing (3-5). It plays an important role in anti-fungal immunity by acting as a pattern recognition receptor for β-glucans found on the cell wall of fungi and some bacteria (5,6). Dectin-1 is composed of a short amino-terminal cytoplasmic domain containing an ITAM-like motif, a transmembrane domain, and an extracellular carboxy-terminal C-type lectin domain (5). Dectin-1 recognizes β-glucans through its C-type lectin domain and transduces signals through its ITAM-like motif by recruiting and activating Syk (7,8). Dendritic cells activated through Dectin-1 promote differentiation of Th17 cells by producing IL-6 and IL-23 (9). Dectin-1 may also play a role in neurodegenerative diseases. , the gene that encodes Dectin-1, is upregulated in microglia, the resident macrophages of the brain, in mouse neurodegenerative disease models, including Alzheimer's disease (10).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nbeta-; Beta-glucan receptor; beta-GR; Bgr; C-type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12; C-type lectin domain family 7 member A; C-type lectin domain family 7, member a; C-type lectin superfamily member 12; CD369; CLC7A; Clec7a; Clecsf; Clecsf12; DC-associated C-type lectin 1; dectin; Dectin-1; Dectin1; Dendritic cell-associated C-type lectin 1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: M\nSENSITIVITY: Endogenous\nMW (kDa): 10, 22\nSOURCE: Rabbit","brand":"CST","offers":[{"title":"Default Title","offer_id":46801052500137,"sku":"23042S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23042s","provider":"Iright","version":"1.0","type":"link"}