{"product_id":"cst-23050t","title":"CST,  23050T, CELA2A (E1D6G) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CELA2A. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, CELA2A (E1D6G) Rabbit Monoclonal Antibody (CST #23050) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCELA2A (E1D6G) Rabbit Monoclonal Antibody recognizes endogenous levels of total CELA2A protein.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly176 of human CELA2A protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nChymotrypsin-like elastase family member 2A (CELA2A) was initially described as an exocrine elastase, produced by exocrine cells of the mammalian pancreas (1,2). Deeper examination revealed additional, lower levels of CELA2A expression by a small subset of pancreatic islet cells and many other tissues, including the adrenal glands, intestine and colon, liver, and white adipose tissue (3). Notably, gene expression datasets have reported aberrant CELA2A expression by other tissues in association with specific disease states (e.g., insulin resistance or Type II diabetes) (3), while increased expression of CELA2A by colonic epithelial cells was reported in patients with inflammatory bowel diseases (4). CELA2A is a secreted protease; in normal physiology, it is released into circulation following an elevation in plasma glucose levels, where it promotes both insulin secretion and degradation, leading to increased insulin sensitivity (3). Importantly, mutations in the gene were shown to inhibit the ability of CELA2A to regulate insulin dynamics (3). Collectively, these studies suggest that CELA2A may be an attractive therapeutic target in both metabolic and inflammatory diseases.\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nAOMS4; CEL2A; CELA2A; chymotrypsin like elastase 2A; chymotrypsin like elastase family member 2A; Chymotrypsin-like elastase family member 2A; chymotrypsin-like elastase family, member 2A; ELA2A; elastase 2A; Elastase-2A; pancreatic elastase 2; pancreatic elastase IIA; PE-1\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Endogenous\nMW (kDa): 26\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797663600809,"sku":"23050T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23050t","provider":"Iright","version":"1.0","type":"link"}