{"product_id":"cst-23368s","title":"CST,  23368S, Cathepsin Z (F6D7U) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying CTSZ. Validated for Western Blotting,Simple Western™,Immunohistochemistry (Paraffin). Available in 2 sizes. Highly specific and rigorously validated in-house, Cathepsin Z (F6D7U) Rabbit Monoclonal Antibody (CST #23368) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nSimple Western™: 1:10 - 1:50\nImmunohistochemistry (Paraffin): 1:500 - 1:2000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunohistochemistry (Paraffin)\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nCathepsin Z (F6D7U) Rabbit Monoclonal Antibody recognizes endogenous levels of total cathepsin Z protein. Non-specific staining was observed in human salivary gland and in cardiomyocytes by immunohistochemistry.\nSpecies Reactivity: Human, Mouse, Rat\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asn75 of human cathepsin Z protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nCathepsin Z, also known as cathepsin X or cathepsin P, is a lysosomal cysteine proteinase member of the papain family encoded by the gene (1,2). It contains a uniquely short pro-domain containing an RGD integrin binding sequence, allowing functionality in cell adhesion, signaling, and extracellular matrix remodeling (3,4). Cathepsin Z is expressed in immune cells, specifically macrophages, monocytes, and dendritic cells, where it participates in several immune cell functions (5). It may play a role in tumorigenesis and has been implicated in several cancer types, including hepatocellular carcinoma, glioblastoma, non-small cell lung cancer, prostate cancer, and colorectal cancer (6-10). Cathepsin Z is also expressed and secreted by activated microglia in the brain and may play a role in neuroinflammation (11,12).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\ncarboxypeptidase LB; cathepsin B2; cathepsin IV; Cathepsin P; Cathepsin X; cathepsin Y; Cathepsin Z; cathepsin Z1; CATZ; CTSX; CTSZ; cysteine-type carboxypeptidase; FLJ17088; lysosomal carboxypeptidase B; preprocathepsin P\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H M R\nSENSITIVITY: Endogenous\nMW (kDa): 33\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797665960105,"sku":"23368S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23368s","provider":"Iright","version":"1.0","type":"link"}