{"product_id":"cst-23542t","title":"CST,  23542T, EXOSC2 (F6Y3J) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying RRP4. Validated for Western Blotting,Immunoprecipitation. Available in 2 sizes. Highly specific and rigorously validated in-house, EXOSC2 (F6Y3J) Rabbit Monoclonal Antibody (CST #23542) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\nImmunoprecipitation: 1:50\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting, Immunoprecipitation\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nEXOSC2 (F6Y3J) Rabbit Monoclonal Antibody recognizes endogenous levels of total EXOSC2 protein. This antibody detects a 90 kDa protein of unknown origin.\nSpecies Reactivity: Human, Monkey\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu14 of human EXOSC2 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nExosome component 2 (EXOSC2), also known as RRP4, is part of the exosome complex involved in RNA processing and mRNA decay by utilizing 3'-5' exoribonuclease activity (1,2). The exosome consists of an inert ring of nine subunits coupled with the enzyme DIS3 or DIS3L (3-5). EXOSC2, along with EXOSC1 and EXOSC3, forms the cap of the complex and assists in 5.8S rRNA generation and mRNA degradation (1,6). Missense mutations in alter exosome binding to certain mRNAs and cause a syndrome termed SHRF (short stature, hearing loss, retinitis pigmentosa, and distinctive facies) (7,8). Overexpression of EXOSC2 was shown to promote metastatic breast cancer in a tRNA-dependent manner (9).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nEXOS2; EXOSC2; Exosome complex component RRP4; Exosome complex exonuclease RRP4; Exosome component 2; homolog of yeast RRP4 (ribosomal RNA processing 4), 3' 5' exoribonuclease (RRP4); homolog of yeast RRP4 (ribosomal RNA processing 4), 3'-5'-exoribonuclease; hRrp4p; p7; Ribosomal RNA-processing protein 4; RRP4; Rrp4p; SHRF\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H Mk\nSENSITIVITY: Endogenous\nMW (kDa): 29\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797667270825,"sku":"23542T","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23542t","provider":"Iright","version":"1.0","type":"link"}