{"product_id":"cst-23567s","title":"CST,  23567S, TRIM7 (E3P2Q) Rabbit Monoclonal Antibody","description":"Monoclonal Antibody for studying TRIM7. Validated for Western Blotting. Available in 2 sizes. Highly specific and rigorously validated in-house, TRIM7 (E3P2Q) Rabbit Monoclonal Antibody (CST #23567) is ready to ship.\n\n\u003cb\u003eProduct Usage Information\u003c\/b\u003e\nWestern Blotting: 1:1000\n\u003cb\u003eStorage\u003c\/b\u003e\nSupplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg\/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at -20°C. Do not aliquot the antibody.\n\u003cb\u003eProtocol\u003c\/b\u003e\nAvailable protocols: Western Blotting\n\u003cb\u003eSpecificity \/ Sensitivity\u003c\/b\u003e\nTRIM7 (E3P2Q) Rabbit Monoclonal Antibody recognizes overexpressed levels of total TRIM7 protein. This antibody is predicted to detect multiple human TRIM7 isoforms.\nSpecies Reactivity: Human\n\u003cb\u003eSource \/ Purification\u003c\/b\u003e\nMonoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala225 of human TRIM7 protein.\n\u003cb\u003eBackground\u003c\/b\u003e\nE3 ubiquitin-protein ligase TRIM7 (TRIM7, RNF90, GNIP) is a member of the tripartite motif-containing (TRIM) family of E3 ubiquitin ligases that mediate protein degradation by the ubiquitin-proteasome system (1,2). The gene has four human isoforms and plays roles in metastasis of cancers, enterovirus replication, and the innate immune response (1-5). TRIM7 inhibits DNA virus-triggered innate immune responses by promoting ubiquitination and subsequent degradation of STING1 (3,6). TRIM7 targets mitochondrial antiviral signaling protein (MAVS) for degradation and negatively regulates antiviral responses against RNA viruses (4,6).\n\u003cb\u003eAlternate Names\u003c\/b\u003e\nE3 ubiquitin-protein ligase TRIM7; Glycogenin-interacting protein; GNIP; RING finger protein 90; RNF90; TRIM7; tripartite motif containing 7; tripartite motif protein TRIM7; tripartite motif-containing 7; Tripartite motif-containing protein 7\n\n\u003cb\u003eSpecification\u003c\/b\u003e\n\nREACTIVITY: H\nSENSITIVITY: Transfected Only\nMW (kDa): 57\nSource\/Isotype: Rabbit IgG","brand":"CST","offers":[{"title":"Default Title","offer_id":46797667369129,"sku":"23567S","price":0.99,"currency_code":"USD","in_stock":true}],"url":"https:\/\/iright.com\/products\/cst-23567s","provider":"Iright","version":"1.0","type":"link"}